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文章来源:优发国际_优发国际官方登录

  近二十年来,随着蛙类人工养殖业的兴盛,一种传染性蛙类疾病在养殖场中频繁爆发。病蛙表现出歪头、运动平衡丧失、眼部晶状体混浊或充血、畏光、身体水肿等症状,继而发生爆发性地死亡。这种传染性疾病俗称为蛙“脑膜炎”、“白内障”或“歪头病”。从九十年代开始,歪头病的爆发从福建、海南等沿海地区逐渐向内陆地区扩散,受危害的养殖蛙类包括牛蛙(Lithobates catebianus)、虎纹蛙(Hoplobatrachus chinensis)、黑斑蛙(Pelophylax nigromaculatus)、棘胸蛙(Quasaipaa spinosa)和棘腹蛙(Quasipaa boulengeri)等重要的经济物种,在对养殖户造成巨大经济损失的同时,也带来新的食品安全问题。 

  已有的研究表明,蛙类歪头病的致病因子为细菌,目前已经从各类病蛙中鉴定出十几株病原菌,包括: 米尔伊丽莎白菌(Elizabethkingia miricola)、脑膜脓毒性伊丽莎白菌(E. meningoseptica)、肺炎克雷伯菌(Klebsiella pneumoniae)、醋酸钙不动杆菌(Acinetohacter calcoaceticus)等,并以伊丽莎白菌属最为常见。这些菌株多为多重耐药菌,其中一些菌株(如米尔伊丽莎白菌)与人类临床分离株(可引起新生儿脑膜炎)具有较高的亲缘关系。当前,虽然对于歪头病致病因子的鉴定工作取得了一定进展,但其病理机制却极少有研究,且优发国际对于健康蛙类所携带的本底病原菌的丰度及其潜在感染途径等均不了解,这些研究的空缺使得养殖蛙类歪头病优发国际的防治工作迟迟无法取得进展。 

  WEICI,ZHONGGUOKEXUEYUANCHENGDOUSHENGWUYANJIUSUOJIANGJIANPINGYANJIUTUANDUIDEZHUWEI、CHANGLIMINGHEZHAOCHUNLINDIAOCHALESICHUANJINGNEIYANGZHIHEIBANWA(SUCHENGQINGWA)DEWAITOUBINGBAOFAQINGKUANG。FAXIANJIBINGBAOFADEWACHANGNEIZHISHAOCUNZAILIANGZHONGLEIXINGDEBINGWA: QIZHONGYIZHONGJINBIAOXIANCHUWAITOUDEZHENGZHUANG,QIYUNDONGPINGHENGSANGSHI,DALIANGNISI;LINGYIZHONGTONGSHIBIAOXIANCHUWAITOU、BAINEIZHANGHEFUZHONGDENGZHENGZHUANG,JIERYUYINANCHUBINGSI(TU1)。TONGGUOBIJIAOWUZHENGZHUANGGETI、WAITOUGETIHE“WAITOU+BAINEIZHANG”GETIDENAO、YANQIUHEXIAOHUADAOJUNQUNFAXIAN,MIERYILISHABAIJUNSHIZHEIXIEBINGWADEZHIBINGYINZI,QIZAILIANGZHONGBINGWADENAOZHONGJUNJUYOUHENGAODEFENGDU,ERJINZAI“WAITOU+BAINEIZHANG”GETIDEYANQIUZHONGJUYOUGAOFENGDU。SUOYOUGETIDEXIAOHUADAOJUNQUNZHONGMIERYILISHABAIJUNDEFENGDUJIDI,SHUOMINGQICONGXIAOHUADAOGANRANHEIBANWADEKENENGXINGJIAODI。ZHIDEZHUYIDESHI,DUOZHONGQITALEIXINGDEWAITOUBINGZHIBINGJUNYICUNZAIYUYANGZHIHEIBANWADETIBIAOHUOCHANGDAOZHONG,SUIRANQIBUSHICICIJIBINGBAOFADEZHIBINGYINZI,DANSHIQUEYOUYINQIWAITOUBINGBAOFADEQIANZAIKENENG。 

   

  TU1 BUTONGZHENGZHUANGDEBINGWAHEWEISHENGWUZUCHENGFENXI

  ZUZHIBINGLIXUEFENXIFAXIAN,WAITOUGETIBIAOXIANCHUMINGXIANDENAOMOXUEGUANCHONGXUE,ER“WAITOU+BAINEIZHANG”GETIHAIEWAIBIAOXIANCHUMINGXIANDERUANNAOMOLINBAXIBAOSHENTOUYIJIZHONGSHUSHENJINGXITONGSUNSHANG;LIANGZHONGBINGWAJUNCHUXIANGANZANGZHIFANGCHUBEIJIANGDIDEXIANXIANG。BINGWAYUWUZHENGZHUANGGETIDEZHUYAOJIYINBIAODACHAYICUNZAIYUNAOZUZHIZHONG,QIEZHEIXIECHAYIJIYINZHUCANYUMIANYIFANYING,BINGWABIAOXIANCHUMIANYISHIBIE(NOD-like receptor signaling pathway and Toll-like receptor signaling pathway)、FAYANFANYING(TNF signaling pathway and Cytokine-cytokine interaction)HESHIYINGXINGMIANYIYINGDA(B cell receptor signaling pathway)DEQUANMIANJIHUO。LIANGLEIBINGWADEJIYINBIAODAZAINAOZUZHIHEGANZANGZHONGCUNZAIMINGXIANCHAYI。ZAINAOZUZHIZHONG,“WAITOU+BAINEIZHANG”GETIBIAOXIANCHUQIANGLIEDETIANRANMIANYIHEYANZHENGYINGDA,QIEJIXINGQIDANBAIDEZHUANLUSHUIPINGXIANZHUSHENGGAO;ZAIGANZANGZHONG,“WAITOU+BAINEIZHANG”GETITONGYANGBIAOXIANCHUGENGXIANZHUDEJIXINGQIDANBAIBIAODASHANGDIAOHENENGLIANGDAIXIEJIYINXIADIAO。ZHEIXIEJIEGUOGONGTONGTISHILIANGZHONGBINGWACHUYUNAOBUGANRANDEBUTONGBINGLIJIEDUAN。JIEHERENXIJUNXINGNAOMOYANDEBINGCHENG,YOUFAGUOJITUICEWAITOUGETICHUYURUANNAOMOQINRUHEGANRANDEZAOQI,HAIWEIYINFANAOMOYAN;YOUYUWEIFAXIANWAITOUGETIDEJIROUCUNZAIMINGXIANDEBINGLIHEJIYINZHUANLUBIANHUA,YINCIYOUFAGUOJITUICEWAITOUZHENGZHUANGHEYUNDONGSHIHENGKENENGSHIYUANYUSHENJINGXITONGGANRAN。ERZAI“WAITOU+BAINEIZHANG”GETIZHONG,GANRANYIJINGYINQINAOMOYAN,QISUOBANSUIDEXITONGXINGFAYANKEDAOZHI“XUEYANPINGZHANG”DETUPO(YANBUGANRAN)HEZUZHISHUIZHONG,JINERJIESHILEWEIHE“BAINEIZHANG”ZHENGZHUANGDECHUXIANKEYIYUCENAOMOYANDEFASHENG(TU2)。 

   

  TU2 DIANXINGZHENGZHUANGDEBINGLIJIZHI

  JIYUZHEIXIEJIEGUO,YOUFAGUOJIWEIWAITOUBINGDEYUFANGTICHUYIXIAJIDIANJIANYI:  

优发国际  1.CHUXIANWAITOUZHENGZHUANGSHIBINGYUANJUNYIRUQINNAOMO,KANGSHENGSUZHILIAOSUODAOZHIDEXIJUNLIEJIEKENENGCUJINYANZHENGFANYING,JIASUBINGWADESIWANG,YINCIGAIJIBINGYINGYIYUFANGWEIZHU; 

  2.YOUYUDUOZHONGZHIBINGJUNBEIHEIBANWAZHENGCHANGXIEDAI,JIANCEHEIBANWATIBIAOJIYANGZHIHUANJINGDEWEISHENGWUZUCHENGHEFENGDUHUOKEYUCEWAITOUBINGBAOFADEFENGXIAN; 

  3.YOUYANJIUBIAOMINGLIANGQIDONGWUZAIBAOLUYUMOUXIEMIEHUODEBINGYUANWUZHIHOURENGKEHUODEMIANYIJIYI,ERYILISHABAIJUNGANRANKEJIHUOHEIBANWADESHIYINGXINGMIANYI,YOUFAGUOJIHUOKECHANGSHISHIYONGMIEHUOBINGYUANJUNBAOLUDEFANGSHITIQIANJIHUOHEIBANWADUIGAIBINGYUANJUNDEDEMIANYINENGLI。 

优发国际  GAIYANJIUDEDAOLEZHONGGUOKEXUEYUANZHANLVEXIANDAOYANJIUXIANGMU(XDA19050201), GUOJIAZIRANKEXUEJIJINXIANGMU(31900327), ZHONGGUOKEXUEYUANXIBUZHIGUANGRENCAIPEIYANGXIANGMU(2016XBZG_XBQNXZ_B_008), YIJISICHUANSHENGKEJITINGJICHUTIAOJIANPINGTAIYOUFAGUOJIXIANGMU(2019JDPT0020)DEZHIZHU。JINRI,ZHEIXIANGGONGZUOYICHANGLIMINGWEIDIYIZUOZHE,TIWEI “Microbiomic and transcriptomic insight into the pathogenesis of meningitis-like disease in cultured Pelophylax nigromaculatus”FABIAOYUSHUICHANLINGYUJINGDIANQIKANAquaculture。

  

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